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Author name: emma.scrafton

Hi, I'm Emma, and I work within the Marketing team at Lhasa Limited. I have a masters degree in Chemistry.

Richard Williams memorial award winner

Interview with Caitlin Maggs, winner of the 2024 Richard Williams Memorial Award

The 2024 Richard Williams Memorial Award was proudly presented during the 37th annual Industrial Genotoxicology Group (IGG) meeting in Cambridge last December. This prestigious award, created to honour Dr Richard Williams, celebrates exceptional scientific contributions while supporting early-career researchers in the field of genotoxicology. Last year’s winner, Caitlin Maggs, is a second-year PhD student at […]

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Why prevalence shifts matter in machine learning

Why prevalence shifts matter in machine learning

In machine learning, the validation of binary classifiers, algorithms that categorise data into two classes, is essential. However, a frequently overlooked issue is prevalence shift, which occurs when two test datasets have different rates of positive instances. This phenomenon can distort performance metrics, leading to incorrect model evaluations. Understanding the problem Prevalence shift fundamentally affects

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2024 Lhasa Publication Award Winners

Celebrating excellence, our top publications of 2024

We recently invited our scientific community to vote for their favourite Lhasa 2024 publication across 3 categories: Toxicology (excluding nitrosamines), Toxicology (specifically nitrosamines) and Chemistry. These awards not only recognise exceptional contributions by Lhasa scientists, but also highlight impactful research that drives progress in our fields and informs the direction of future publications.  The winners

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Sarah Nexus frequently asked questions

Everything you need to know about Sarah Nexus

The use of in silico prediction systems has become an essential part of regulatory submissions when assessing the genotoxic potential of chemicals. Guidelines such as those from the EMA, US FDA, and ICH highlight their importance. Most notably, the ICH M7 guidance explicitly requires the application of two complementary quantitative/qualitative structure-activity relationship ((Q)SAR) systems to

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EUROTOX 2024: A memorable gathering in Copenhagen

EUROTOX 2024: Advancing toxicology in Copenhagen

We had a fantastic time at EUROTOX 2024, held from 8 – 11th September in the picturesque city of Copenhagen, Denmark. This year’s theme, “Toxicology – A Quest for Safe Chemicals and Medicines”, was reflected in the diverse sessions, posters and presentations throughout the event. Key topics ranged from the safety of drugs and environmental

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A step towards animal-free developmental and reproductive toxicity safety assessments

Developmental and reproductive toxicity (DART) is a critical area of toxicology that is required to assess the impact of new chemicals on adult fertility and embryo development. Industries across the globe rely on DART assessments to safeguard human health, adhering to regulatory standards like those outlined in the ICH S5 (R3) guideline. However, the current

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10 frequently asked questions about Derek Nexus, answered

For over four decades, at Lhasa Limited we have been developing scientific software solutions that enable scientists to make informed decisions on the safety of drugs, chemicals and cosmetics. Our journey advanced significantly with the creation of Derek Nexus, an in silico expert knowledge-based toxicity prediction tool. As regulatory landscapes evolved and the push for

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Supporting the safe use of CDB in skincare products using Derek Nexus

Supporting the safe use of CBD in skincare products using Derek Nexus

Cannabidiol (CBD) is gaining prominence as a sought-after ingredient in skincare and beauty formulations, thanks to its notable anti-inflammatory, antioxidant and anti-bacterial properties. Derived directly from the hemp plant, this compound is increasingly being used as an ingredient in skincare products, particularly for the management of various skin conditions like eczema, dermatitis and psoriasis. Despite

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Scientist Spotlight: Poster Shortlisted for Top 10 Best Risk Assessment Abstract at Society of Toxicology!

Scientist Spotlight: Poster Shortlisted for Top 10 Best Risk Assessment Abstract at Society of Toxicology!

One of our three Lhasa Limited posters during the recent Society of Toxicology 63rd annual meeting was selected for the top 10 best risk assessment abstract award by the Risk Assessment Speciality Section! Authored by Lhasa scientist, Pooja Tomar, the poster titled “Best practice for conducting expert review of sensitisation data and predictions​” highlights the critical

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Lhasa Limited publication awards 2023

The ultimate 2024 reading list, as chosen by our members!

Throughout 2023, our dedicated team contributed significantly to various journals through authoring and co-authoring a plethora of publications. Here are the articles, as voted by our members, which stood out above the rest. Organised into 5 compelling categories; Extractables and Leachables, Nitrosamines, Potentially Mutagenic Impurities (PMIs), Data Sharing and Safety Profiling in Drug Discovery, we

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