Author name: lhasalimited

There are many risks associated with trusting a poorly written structural alert; an incorrect prediction could result in wasted time and money. At Lhasa Limited, we take pride in the accuracy and consistency of our products. This article aims to elucidate alert reliability and discuss the process of expert driven alert creation in Derek Nexus. […]

In July 2020, we announced the introduction of an annual award – expected to run until 2024 – honouring the scientific contributions and memory of Dr. Richard Williams. It is with huge excitement that today, we are able to introduce you to the first winner of the Richard Williams Memorial Award, Amy Wilson. Amy is an

Zeneth is Lhasa’s expert, knowledge-based in silico software for the prediction of forced degradation pathways of organic active pharmaceutical ingredients (APIs). Zeneth can provide knowledge and mechanistic understanding of the potential chemical degradation pathways of APIs under defined environmental conditions; those typically used in forced degradation studies (temperature, pH, water, oxygen, peroxide, light, metal ions,

Lhasa Limited has been an advocate of data sharing for many years. In this piece, we explore the top 5 benefits of data sharing within Vitic. The benefits of data sharing include cost savings, the ability to make more informed decisions and the opportunity to define best practice through collaboration within the industry. Vitic is central to

In a world where we are all striving for progress, technology is also advancing quickly. Like many organisations across the life sciences industry – evidenced by > 80 Amazon Web Service (AWS) life sciences case studies –  Lhasa has adopted cloud, Software as a Service (SaaS), options across three notable areas: Mirabilis – reducing analytical testing by

Are you interested in collaboratively using data to predict and avoid adverse drug reactions? The Effiris consortium – currently composed of Takeda, GSK and UCB – is working to achieve just that. The project aims to help pharmaceutical organisations accelerate drug discovery through machine learning. Many readers will be very familiar with the fact that one

Lhasa Limited, in collaboration with Leadscope, Inc., are leading a working group of pharmaceutical toxicologists and consultants investigating the carcinogenic potency and structure-activity relationships of N-nitrosamines. This is in response to the recent discovery of N-nitrosamines in marketed pharmaceuticals and the regulatory changes that have resulted. The working group is coordinated on an informal basis

Introduction to Lhasa Carcinogenicity Database For many years the Carcinogenic Potency Database (CPDB)1, created by Lois Gold and her team, was an important source of long-term carcinogenicity study data. However, as the database had stopped being updated from 2007, Lhasa moved to safeguard the data by providing ongoing access through a freely available interface; the Lhasa

The introduction of purge arguments by Teasdale et al. has had a huge impact on the way in which companies consider the quality of their drug substances with respect to potentially mutagenic impurities (PMIs), allowing chemists to utilise their inherent knowledge of the physicochemical properties of the impurities within the synthetic process.1 This encourages a