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Explore topical blogs discussing chemical safety assessment.

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Advancing drug discovery though data-driven federated learning

A new paper, “Data-driven federated learning in drug discovery with knowledge distillation”, was recently published in Nature Machine Intelligence, the leading journal for Machine Learning and AI. It explores the potential for federated learning to advance drug discovery through secure, collaborative research, representing a major step forward in privacy-preserving machine learning.   What is Federated […]

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How to overcome the critical challenges faced in forced degradation studies

At Lhasa we know that there are many challenges involved in carrying out risk assessments for drug substances and drug products, to ultimately ensure a safe and effective product for patients. Forced degradation studies are essential in pharmaceutical development to assess drug stability and ensure product quality and safety. These studies help identify degradation pathways,

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Anvisa RDC 964/2025: What you need to know about the latest regulatory update

The Brazilian Health Regulatory Agency (Anvisa) has introduced RDC 964/2025, a new guidance that outlines in more detail the requirements for conducting forced degradation studies. This new regulation replaces RDC 53/2015, aligning the requirements for forced degradation studies with international (ICH) standards. At Lhasa we are keen to support our members working in this field

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Richard Williams memorial award winner

Interview with Caitlin Maggs, winner of the 2024 Richard Williams Memorial Award

The 2024 Richard Williams Memorial Award was proudly presented during the 37th annual Industrial Genotoxicology Group (IGG) meeting in Cambridge last December. This prestigious award, created to honour Dr Richard Williams, celebrates exceptional scientific contributions while supporting early-career researchers in the field of genotoxicology. Last year’s winner, Caitlin Maggs, is a second-year PhD student at

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Where can N-Nitrosamine data support an alternative AI beyond the CPCA?

Where can N-Nitrosamine data support an alternative AI beyond the CPCA?

The recently published paper “Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes,” presents evidence for evolving the pharmaceutical industry’s approach to N-nitrosamine risk assessment. While the Carcinogenic Potency Categorisation Approach (CPCA) has provided a solid framework for managing N-nitrosamine drug substance-related

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Sarah Nexus frequently asked questions

Everything you need to know about Sarah Nexus

The use of in silico prediction systems has become an essential part of regulatory submissions when assessing the genotoxic potential of chemicals. Guidelines such as those from the EMA, US FDA, and ICH highlight their importance. Most notably, the ICH M7 guidance explicitly requires the application of two complementary quantitative/qualitative structure-activity relationship ((Q)SAR) systems to

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A new life in Leeds at Lhasa 8

Lhasa speaks with the 2023 Richard Williams Award Winner

The Richard Williams Memorial Award, established in 2020, honours the scientific contributions and memory of Dr. Richard Williams. This award recognises exceptional early-career investigators making significant strides in their fields, with winners presenting their work at the Lhasa head office and the Annual Industrial Genotoxicology Group (IGG) Meeting . We are thrilled to introduce the

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10 FAQs About Mirabilis: Pharmaceutical Impurity Control Using In Silico Tools

Identification and control of impurities in active pharmaceutical ingredients (APIs) and pharmaceutical drug products is critical in drug development. Mirabilis is our innovative solution designed to address this challenge. In this post, we’ll answer ten frequently asked questions about Mirabilis.   What is Mirabilis? Mirabilis is an in silico tool developed by Lhasa Limited that

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EUROTOX 2024: A memorable gathering in Copenhagen

EUROTOX 2024: Advancing toxicology in Copenhagen

We had a fantastic time at EUROTOX 2024, held from 8 – 11th September in the picturesque city of Copenhagen, Denmark. This year’s theme, “Toxicology – A Quest for Safe Chemicals and Medicines”, was reflected in the diverse sessions, posters and presentations throughout the event. Key topics ranged from the safety of drugs and environmental

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