Explore topical blogs discussing chemical safety assessment.
If you couldn’t join us for our recent webinar, “Identifying the Formation of Nitrosamines via Degradation Pathways Using an In-Silico Approach,” we’ve got you covered! We explored how Zeneth, our cutting-edge software solution, can help you detect potential degradation issues early in the drug development workflow, specifically in the context of nitrosamine risk assessment. We […]
Nitrosamines, a class of chemical compounds known for their potential carcinogenic properties, have become a significant concern for the pharmaceutical industry. In line with revised guidance from the European Medicines Agency (EMA), regulatory agencies require N-nitrosamines risk assessments to be performed on all marketed medical products investigating nitrosamine formation potential and their mutagenic and carcinogenic
For over four decades, at Lhasa Limited we have been developing scientific software solutions that enable scientists to make informed decisions on the safety of drugs, chemicals and cosmetics. Our journey advanced significantly with the creation of Derek Nexus, an in silico expert knowledge-based toxicity prediction tool. As regulatory landscapes evolved and the push for
10 frequently asked questions about Derek Nexus, answered Read More »
Explore key insights from the Lhasa Limited and IPEC Europe Nitrites meeting, where attendees discussed advancing nitrosamine understanding. “The meeting provided an opportunity to share our common difficulties and discuss solutions to establish robust and accurate methods for analysing nitrites in excipients.” We recently welcomed members of the Lhasa Nitrites data sharing consortium and
Key insights from the Lhasa Limited & IPEC Europe Nitrites meeting Read More »
Cannabidiol (CBD) is gaining prominence as a sought-after ingredient in skincare and beauty formulations, thanks to its notable anti-inflammatory, antioxidant and anti-bacterial properties. Derived directly from the hemp plant, this compound is increasingly being used as an ingredient in skincare products, particularly for the management of various skin conditions like eczema, dermatitis and psoriasis. Despite
Supporting the safe use of CBD in skincare products using Derek Nexus Read More »
Diversity serves as a catalyst for innovation at Lhasa. We believe in cultivating a workplace culture that encourages collaboration, and empowers every individual to express themselves fully. Art has the power to promote a culture of creativity, self-expression and community playing an integral role in enriching the fabric of our environment. Serving as a powerful
Fostering cross-cultural connections through art Read More »
Following the success of the 2022 Science of Stability (SOS) Conference in Philadelphia, we’re excited to announce its return to Barcelona! The 8th SOS will take place on the 13-14th May 2024, and we’re delighted to co-host it with FreeThink Technologies. With a focus on innovation and collaboration, this promises to be a milestone event
Insights into the 2024 Science of Stability Conference Read More »
We are delighted to share our important new open access article: In silico prediction of pharmaceutical degradation pathways: A benchmarking study using the software program Zeneth. The paper, recently published in Organic Process Research & Development (OPRD) is authored by Lhasa Principal Scientist Rachel Hemingway, alongside industry expert co-authors from AstraZeneca, GSK, Pfizer, BMS, Amgen
At Lhasa, we believe in the transformative power of knowledge sharing as the driving force to support the global challenge of nitrosamine risk assessment. Through data sharing and industry collaboration, we empower members to further understand the risks associated with their potential nitrosamine impurities. The Vitic Complex Nitrosamines initiative, launched in 2021 in response to
Mitigating the risks of NDSRI’s through data sharing Read More »
Building on the success of our recent webinar, How to establish acceptable intake (AI) limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs), we’re thrilled to present a follow-up that brings you closer to the insightful discussions that unfolded during the interactive Q&A session. In this blog, we’ve gathered questions posed during the webinar and curated written
Q&A deep dive with Martin Walter: How to establish AI limits for NDSRIs Read More »