Lhasa Limited is delighted to announce the release of new data to the Vitic Aromatic Amines database.
This pre-competitive data sharing initiative facilitates anonymous sharing of Ames data on primary aromatic amines, enabling the refinement of structure-activity relationships (SARs), and the development of improved predictive tools.
The data is housed on a secure user management system, allowing cross-database searches to consider the published data in parallel to the Aromatic Amines proprietary data. As a result, members can quickly and easily search for structurally similar compounds, facilitating the selection of relevant data for read-across in their risk assessments.
New data release
With the latest update, the Vitic Aromatic Amines 2024.1.0 database now contains:
- 1,174 new data records, bringing the total to 20,640.
- 70 new substances, bringing the total to 1,251.
An update to note is the addition of 1,104 genetic toxicity in vitro data records within the database – bringing the total number of data records to 19,389. The new data records relate to 70 substances, all of which are new substances.
Among the new structures, coverage continues to improve, specifically for polysubstituted anilines and heterocyclic primary aromatic amines, ensuring the diversification of the dataset for these compounds, which are highly relevant to drug synthesis.
Why join the Vitic Aromatic Amines data sharing initiative?
By participating in the Consortium for the Investigation of the Genotoxicity of Aromatic Amines (CIGAA), members are actively contributing to industry progression towards an improved understanding and predictability of the Ames test outcome for this challenging chemical class.The sharing of aromatic amines Ames data reduces testing duplication, avoiding the need to repeat potentially costly experiments. The shared data can inform decisions in the synthesis planning process, allowing users to avoid problematic compounds and unnecessary testing.
Interested in joining the consortium? Get in touch with the Lhasa team.