Unlock rich Ames data and other new genetic toxicity records in the latest update to the Vitic Complex Nitrosamines database.
Lhasa Limited is excited to share a variety of new data releases as part of our pre-competitive data sharing initiative, supporting knowledge sharing to enhance understanding of structure-activity relationships (SAR) in complex nitrosamines.
By supporting collaboration on the anonymous exchange of genetic toxicology data, the initiative provides access to a chemically diverse dataset and facilitates the identification of trends in mutagenic activity associated with specific chemical features. Gain understanding of SARs for the nitrosamines class through our newest data release, which predominantly includes Ames data.
New data release at a glance
The Vitic Complex Nitrosamines 2025.1.0 database update includes:
• A total of 340 new data records, increasing the current count to 4,192.
• A total of 10 new substances, resulting in 136 total substances.
Growing genetic toxicity data records
Focusing specifically on data records relating to in vitro genetic toxicity, the database now contains 3,991 relevant data records and 131 substances with associated bacterial mutagenicity records. This new data contributes to expanded strain and metabolic activation profiles, for increased compound coverage, in line with the enhanced Ames test conditions for N-nitrosamines.
Another enhancement of this database update lies in the addition of new substances which significantly grow the in vivo genetic toxicity dataset. In vivo compound coverage has doubled (from 11 to 22), and the dataset size has increased by 47% (from 38 to 72 study records). This includes key data for mutagenic potency characterisation, such as transgenic rodent and duplex sequencing mutation assay data.
How the Vitic Complex Nitrosamines data sharing initiative works
Consortium members securely contribute data from their internal portfolios or generate new data to support the development of more accurate predictions for this high-concern chemical class. The shared data aids in refining and validating the SAR model for predicting the mutagenic activity of nitrosamines, while also preventing duplication to reduce testing efforts and supporting members in their regulatory submissions.
Our systematic peer-review process ensures access to an anonymised high-quality dataset from the data donated by participating organisations within industry.
Interested in joining the consortium? Please get in touch with the Lhasa team.
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What is the Vitic Complex Nitrosamines database?
It’s a data sharing initiative for exchanging genetic toxicology data on complex nitrosamines, mainly Ames data.
What is the goal of this initiative?
To provide a diverse dataset that helps identify trends in mutagenic activity and understand structure-activity relationships (SAR) for nitrosamines.
What’s new in the Vitic Complex Nitrosamines 2025.1.0 update?
The update includes:
- 340 new data records, totaling 4,192.
- 10 new substances, totaling 136.
What genetic toxicity data does the Vitic Complex Nitrosamines database offer?
It has 3,991 in vitro data records, mainly bacterial mutagenicity records on 131 substances, with expanded strain and metabolic activation profiles.
What’s new in the Vitic Complex Nitrosamines in vivo dataset?
The in vivo dataset now covers 22 compounds (up from 11) and includes 72 study records (up from 38), featuring key data for mutagenic potency characterisation.
How do members contribute complex nitrosamine data?
Members securely share data from their portfolios or generate new data to improve predictions for nitrosamines, refine SAR models, reduce testing efforts, and support regulatory submissions.
How is the Vitic Complex Nitrosamines data quality maintained?
A systematic peer-review process ensures high-quality, anonymised data from participating organisations.
How can I join the Vitic Complex Nitrosamines data sharing initiative?
Please get in touch with the Lhasa team.