Lhasa Limited is excited to announce the latest update to the Vitic Complex Nitrosamines database. This pre-competitive data sharing initiative promotes the anonymous exchange of genetic toxicology data on structurally complex nitrosamines, primarily Ames data.
The initiative provides access to a chemically diverse dataset, facilitating the identification of trends in mutagenic activity associated with specific chemical features. This, in turn, enhances the understanding of structure-activity relationships (SAR) for the nitrosamines class.
New data release
The Vitic Complex Nitrosamines 2025.1.0 database update includes:
• 340 new data records, increasing the total to 4,192.
• 10 new substances, bringing the total to 136.
Genetic toxicity data records
The database now contains 3,991 genetic toxicity in vitro data records, predominantly bacterial mutagenicity records on 131 substances. The new data contributes to increased compound coverage and an expanded strain and metabolic activation profile for previously covered compounds, in line with the enhanced Ames test conditions for N-nitrosamines.
Another asset of this database update lies in the significant growth of the genetic toxicity in vivo dataset. In vivo compound coverage has doubled (from 11 to 22), and the dataset size has increased by 47% (from 38 to 72 study records). This includes key data for mutagenic potency characterisation, such as transgenic rodent and duplex sequencing mutation assay data.
How the Vitic Complex Nitrosamines data sharing initiative works
Consortium members securely contribute data from their internal portfolios or generate new data to support the development of more accurate predictions for this high-concern chemical class. The shared data aids in refining and validating the SAR model for predicting the mutagenic activity of nitrosamines, while also preventing duplication to reduce testing efforts and supporting members in their regulatory submissions.
Our systematic peer-review process ensures access to an anonymised high-quality dataset from the data donated by participating organisations within industry.
Interested in joining the consortium? Please get in touch with the Lhasa team.
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What is the Vitic Complex Nitrosamines database?
It’s a data sharing initiative for exchanging genetic toxicology data on complex nitrosamines, mainly Ames data.
What is the goal of this initiative?
To provide a diverse dataset that helps identify trends in mutagenic activity and understand structure-activity relationships (SAR) for nitrosamines.
What’s new in the Vitic Complex Nitrosamines 2025.1.0 update?
The update includes:
- 340 new data records, totaling 4,192.
- 10 new substances, totaling 136.
What genetic toxicity data does the Vitic Complex Nitrosamines database offer?
It has 3,991 in vitro data records, mainly bacterial mutagenicity records on 131 substances, with expanded strain and metabolic activation profiles.
What’s new in the Vitic Complex Nitrosamines in vivo dataset?
The in vivo dataset now covers 22 compounds (up from 11) and includes 72 study records (up from 38), featuring key data for mutagenic potency characterisation.
How do members contribute complex nitrosamine data?
Members securely share data from their portfolios or generate new data to improve predictions for nitrosamines, refine SAR models, reduce testing efforts, and support regulatory submissions.
How is the Vitic Complex Nitrosamines data quality maintained?
A systematic peer-review process ensures high-quality, anonymised data from participating organisations.
How can I join the Vitic Complex Nitrosamines data sharing initiative?
Please get in touch with the Lhasa team.