Lhasa Limited is excited to announce a significant enhancement to Sarah Nexus, with the introduction of a new chromosome damage prediction model. This additional sponsored module of Sarah Nexus enables users to perform comprehensive genotoxic assessments by enabling mutagenicity and chromosome damage predictions within a single, powerful in silico platform.
The Sarah Nexus chromosome damage model is designed to predict the potential genetic toxicity of chemicals. By leveraging in vitro chromosome aberration and micronucleus assay data, alongside in vivo test data, the model offers a robust and reliable tool for assessing genotoxic risk. All data in the model is curated from the Vitic database and supplemented by proprietary contributions from Lhasa Limited members, ensuring accuracy and relevance. Moreover, the model is built on trusted Sarah Nexus technology, presenting data transparently, allowing you to review and interrogate predictions with confidence.
This additional module enables more efficient candidate screening by identifying high-risk compounds before advancing to costly and time-intensive in vitro or in vivo testing. As regulatory bodies are increasingly requesting in silico predictions for assessments of pesticide metabolites and impurities, this sponsored model becomes an asset for both compliance and innovation.
In addition to the optional chromosome damage model, this release introduces key updates to Derek Nexus and Sarah Nexus, including:
- New expert review arguments, providing deeper insights about the presence and quality of Ames data used to make in silico predictions.
- Custom nitrosamine carcinogenic potency categorisation approach (CPCA) reports, streamlining regulatory submissions and providing essential support for compliance.
- Updated nitrosamine acceptable intake limits, ensuring your assessments remain in alignment with the latest regulatory guidelines.
Watch the video below featuring Dr Robert Foster, Principal Scientist, and Toni Rogers, Senior Application Scientist at Lhasa Limited, to learn more about these exciting updates.
If you’re interested in gaining access to the chromosome damage model in Sarah Nexus, or learning more about Sarah Nexus or Derek Nexus, please get in touch.