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eTox

Statistical analysis of preclinical inter-species concordance of histopathological findings in the eTOX database

Preclinical inter-species concordance can increase the predictivity of observations to the clinic, potentially reducing drug attrition caused by unforeseen adverse events. We quantified inter-species concordance of histopathological findings and target organ toxicities across four preclinical species in the eTOX database using likelihood ratios (LRs). This was done whilst only comparing findings between studies with similar […]

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Retrospective analysis of the potential use of virtual control groups in preclinical toxicity assessment using the eTOX database

Virtual Control Groups (VCGs) based on Historical Control Data (HCD) in preclinical toxicity testing have the potential to reduce animal usage. As a case study we retrospectively analyzed the impact of replacing Concurrent Control Groups (CCGs) with VCGs on the treatment-relatedness of 28 selected histopathological findings reported in either rat or dog in the eTOX

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“Please, sir, I want some more…” data Guidelines for effective sharing of preclinical data

“Please, sir, I want some more…” data Guidelines for effective sharing of preclinical data was presented by Research Leader, Katharine Briggs during EUROTOX 2022. The poster discusses eTRANSAFE data sharing guidelines, including decision criteria for inclusion in internal clearance procedures and criteria for identifying data considered too sensitive to share for substances of strategic interest.

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Introducing the concept of virtual control groups into preclinical toxicology testing 

Sharing legacy data from in vivo toxicity studies offers the opportunity to analyze the variability of control groups stratified for strain, age, duration of study, vehicle, and other experimental conditions. Historical animal control group data collected in a repository could be used to construct virtual control groups (VCGs) for toxicity studies. VCGs are an established concept in

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