Genotoxic impurity evaluation

Sarah Nexus makes predictions for chromosome damage (e.g. all chromosomal aberrations) using fragment-based structural hypotheses derived from a statistically learned self-organising hypothesis network (SOHN) built using chromosome aberration and micronucleus assay data.

Derek Nexus version 6.4 contains 109 alerts for chromosome damage, together with reasoning rules. These describe numerical (e.g. aneugenic) and structural (i.e. clastogenic) chromosomal aberrations in vitro and in vivo. Find current QMRFs here, for historical versions of Derek Nexus and Sarah Nexus, QMRFs can be located within the Nexus help centre.

Derek Nexus version 6.3 contains 108 alerts for chromosome damage, together with reasoning rules. These describe numerical (e.g. aneugenic) and structural (i.e. clastogenic) chromosomal aberrations in vitro and in vivo. Find current QMRFs here, for historical versions of Derek Nexus and Sarah Nexus, QMRFs can be located within the Nexus help centre. View the QMRF

Derek Nexus version 6.2.1 contains 105 alerts for chromosome damage, together with reasoning rules. These describe numerical (e.g. aneugenic) and structural (i.e. clastogenic) chromosomal aberrations in vitro and in vivo. Find current QMRFs here, for historical versions of Derek Nexus and Sarah Nexus, QMRFs can be located within the Nexus help centre.